Researches on entrepreneurship and business enterprise concerning developing nations have normally explored the manners by which, culture, politics, or Cleaver economic institutions disallow or empower entrepreneurial exercises utilizing macro-level surveys and deductive designs.Accordingly, this research aims to evaluate the extent of the contribu
Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3+ Tregs, 5-HTP hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells.Cancer patients with severe immune-related adverse events (irAE) after receiving anti-CTLA-4/PD-1 combination immuno
Objective: Exostosis of the internal auditory canal (IAC) is a rarely reported entity.We present a case of unilateral IAC exostosis with longitudinal radiographic imaging and its associated abnormal neurodiagnostic and audiologic studies.To our knowledge, this is the first documented report of a patient with hyperostosis of the IAC who was Outdoor
The therapeutic promise of Cosmetic Sets small-RNA therapeutics is limited, not only by the lack of delivery vehicles, but also by the inability of the small RNAs to reach intracellular compartments where they can be biologically active.We previously reported successful delivery of functionally active miRNAs via receptor-mediated endocytosis.This t
Background/Aims: More and more literature describes how to overcome challenges in the implementation of adaptive designs for trials for drug approval process.Most adaptive trials were conducted in Western Europe or USA for Phase II or Phase II/III settings; however, examples of non-oncology pivotal adaptive trials used for regulatory approval in Ja